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Critical Medicine, LLC

Resources

  • Research

    Racial/ethnic disparities on inflammation and response to methylprednisolone in severe COVID-19 pneumonia.

    Go RC, Nyirenda, T, Bojarian M et al.

    BMC Infect Dis 22, 254 (2022).

    doi: 10.1186/s12879-022-07237-1

  • Research

    Methylprednisolone, venous thromboembolism, and association with heparin to 30 days in hospital survival in severe Covid-19 pneumonia.

    Go RC, Nyirenda T, Bojarian M, Hosseini DK, Rahim M, Kim K, Rose KM.

    BMC Pulm Med. 2022 Jan 6;22(1):6.

    doi: 10.1186/s12890-021-01810-1

  • Epidemiology/Genetics

    Obesity, inflammatory and thrombotic markers, and major clinical outcomes in critically ill patients with COVID-19 in the US.

    Friedman AN, Guirguis J, Kapoor R, Gupta S, Leaf DE, Timsina LR; STOP-COVID Investigators.

    Obesity (Silver Spring). 2021 Oct;29(10):1719-1730.

    doi: 10.1002/oby.23245

  • Report

    Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States.

    Jezmir JL, Bharadwaj M, Chaitoff A, Diephuis B, Crowley CP, Kishore SP, Goralnick E, Merriam LT, Milliken A, Rhee C, Sadovnikoff N, Shah SB, Gupta S, Leaf DE, Feldman WB, Kim EY; STOP-COVID Investigators.

    Cell Rep Med. 2021 Sep 21;2(9):100376.

    doi: 10.1016/j.xcrm.2021.100376

  • Critical Care: Original Research

    Identification of Distinct Clinical Subphenotypes in Critically Ill Patients With COVID-19.

    Vasquez CR, Gupta S, Miano TA, Roche M, Hsu J, Yang W, Holena DN, Reilly JP, Schrauben SJ, Leaf DE, Shashaty MGS; STOP-COVID Investigators.

    Chest. 2021 Sep;160(3):929-943.

    doi: 10.1016/j.chest.2021.04.062

  • Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.

    REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators, Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, Ahuja T, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Contreras A, Costantini TW, de Brouwer S, Detry MA, Duggal A, Džavík V, Effron MB, Eng HF, Escobedo J, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Froess JD, Fu Z, Galanaud JP, Galen BT, Gandotra S, Girard TD, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Haniffa R, Hegde SM, Hendrickson CM, Higgins AM, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Huang DT, Hudock K, Hunt BJ, Husain M, Hyzy RC, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski A, King AJ, Knudson MM, Kornblith AE, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Gallego Lima F, Linstrum K, Litton E, Lopez-Sendon J, Lother SA, Marten N, Saud Marinez A, Martinez M, Mateos Garcia E, Mavromichalis S, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nicolau JC, Nunez-Garcia B, Park JJ, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pompilio M, Quigley JG, Rosenson RS, Rost NS, Rowan K, Santos FO, Santos M, Santos MO, Satterwhite L, Saunders CT, Schreiber J, Schutgens REG, Seymour CW, Siegal DM, Silva DG Jr, Singhal AB, Slutsky AS, Solvason D, Stanworth SJ, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Widmer RJ, Wilson JG, Yuriditsky E, Zhong Y, Berry SM, McArthur CJ, Neal MD, Hochman JS, Webb SA, Zarychanski R.

    N Engl J Med. 2021 Aug 26;385(9):777-789.

    doi: 10.1056/NEJMoa2103417

  • Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.

    ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators, Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, Escobedo J, Huang DT, Bradbury CA, Houston BL, Kornblith LZ, Kumar A, Kahn SR, Cushman M, McQuilten Z, Slutsky AS, Kim KS, Gordon AC, Kirwan BA, Brooks MM, Higgins AM, Lewis RJ, Lorenzi E, Berry SM, Berry LR, Aday AW, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Costantini TW, de Brouwer S, Derde LPG, Detry MA, Duggal A, Džavík V, Effron MB, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Galanaud JP, Galen BT, Gandotra S, García-Madrona S, Girard TD, Godoy LC, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Hamburg NM, Haniffa R, Hanna G, Hanna N, Hegde SM, Hendrickson CM, Hite RD, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Hudock K, Hunt BJ, Husain M, Hyzy RC, Iyer VN, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski AL, King AJ, Knudson MM, Kornblith AE, Krishnan V, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Lima FG, Linstrum K, Litton E, Lopez-Sendon J, Lopez-Sendon Moreno JL, Lother SA, Malhotra S, Marcos M, Saud Marinez A, Marshall JC, Marten N, Matthay MA, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Moore SC, Morillo Guerrero R, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nunez-Garcia B, Pandey A, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pérez González YS, Pompilio M, Prekker ME, Quigley JG, Rost NS, Rowan K, Santos FO, Santos M, Olombrada Santos M, Satterwhite L, Saunders CT, Schutgens REG, Seymour CW, Siegal DM, Silva DG Jr, Shankar-Hari M, Sheehan JP, Singhal AB, Solvason D, Stanworth SJ, Tritschler T, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Wells BJ, Widmer RJ, Wilson JG, Yuriditsky E, Zampieri FG, Angus DC, McArthur CJ, Webb SA, Farkouh ME, Hochman JS, Zarychanski R.

    N Engl J Med. 2021 Aug 26;385(9):790-802.

    doi: 10.1056/NEJMoa2105911

  • Hemodynamic Profiles of Shock in Patients With COVID-19.

    Hollenberg SM, Safi L, Parrillo JE, Fata M, Klinkhammer B, Gayed N, Glotzer T, Go RC, Gourna-Paleoudis E, Landers D, Jamal S, Shah N, Shah R, Tancredi J, Turi ZG.

    Am J Cardiol. 2021 Aug 15;153:135-139.

    doi: 10.1016/j.amjcard.2021.05.029

  • Methylprednisolone and 60 Days in Hospital Survival in COVID-19 Pneumonia.

    Go RC, Roshan S, Nyirenda T, Oe Y, Sarfraz K, Panthappattu J, Lesley P, Bheeman H, Shah N, Shah, S, Dar S, Sung H, Rahman W, Im H, Marafelias M, Omidvari K, Pradhan A, Sadikot S, Rose KM, Sperber SJ, Josephs J.

    Critical Care Explorations. July 2021;3:7.

    doi: 10.1097/CCE.0000000000000493

  • Prone Positioning and Survival in Mechanically Ventilated Patients With Coronavirus Disease 2019-Related Respiratory Failure.

    Mathews KS, Soh H, Shaefi S, Wang W, Bose S, Coca S, Gupta S, Hayek SS, Srivastava A, Brenner SK, Radbel J, Green A, Sutherland A, Leonberg-Yoo A, Shehata A, Schenck EJ, Short SAP, Hernán MA, Chan L, Leaf DE; STOP-COVID Investigators.

    Crit Care Med. 2021 Jul 1;49(7):1026-1037

    doi: 10.1097/CCM.0000000000004938

  • d-dimer and Death in Critically Ill Patients With Coronavirus Disease 2019.

    Short SAP, Gupta S, Brenner SK, Hayek SS, Srivastava A, Shaefi S, Singh H, Wu B, Bagchi A, Al-Samkari H, Dy R, Wilkinson K, Zakai NA, Leaf DE; STOP-COVID Investigators.

    Crit Care Med. 2021 May 1;49(5):e500-e511.

    doi: 10.1097/CCM.0000000000004917

  • Hospital-Level Variation in Death for Critically Ill Patients with COVID-19.

    Churpek MM, Gupta S, Spicer AB, Parker WF, Fahrenbach J, Brenner SK, Leaf DE; STOP-COVID Investigators.

    Am J Respir Crit Care Med. 2021 Apr 23;204(4):403–11.

    doi: 10.1164/rccm.202012-4547OC

  • Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia.

    Rosas IO, Bräu N, Waters M, Go RC, Hunter BD, Bhagani S, Skiest D, Aziz MS, Cooper N, Douglas IS, Savic S, Youngstein T, Del Sorbo L, Cubillo Gracian A, De La Zerda DJ, Ustianowski A, Bao M, Dimonaco S, Graham E, Matharu B, Spotswood H, Tsai L, Malhotra A.

    N Engl J Med. 2021 Apr 22;384(16):1503-1516.

    doi: 10.1056/NEJMoa2028700

  • Clinical and laboratory evaluation of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma.

    Donato ML, Park S, Baker M, Korngold R, Morawski A, Geng X, Tan M, Ip A, Goldberg S, Rowley S, Chow K, Brown E, Zenreich J, McKiernan P, Buttner K, Ullrich A, Long L, Feinman R, Ricourt A, Kemp M, Vendivil M, Suh H, Balani B, Cicogna C, Sebti R, Al-Khan A, Sperber S, Desai S, Fanning S, Arad D, Go R, Tam E, Rose K, Sadikot S, Siegel D, Gutierrez M, Feldman T, Goy A, Pecora A, Biran N, Leslie L, Gillio A, Timmapuri S, Boonstra M, Singer S, Kaur S, Richards E, Perlin DS.

    JCI Insight. 2021 Mar 22;6(6):e143196.

    doi: 10.1172/jci.insight.143196

  • Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19.

    Shaefi S, Brenner SK, Gupta S, O'Gara BP, Krajewski ML, Charytan DM, Chaudhry S, Mirza SH, Peev V, Anderson M, Bansal A, Hayek SS, Srivastava A, Mathews KS, Johns TS, Leonberg-Yoo A, Green A, Arunthamakun J, Wille KM, Shaukat T, Singh H, Admon AJ, Semler MW, Hernán MA, Mueller AL, Wang W, Leaf DE; STOP-COVID Investigators.

    Intensive Care Med. 2021 Feb;47(2):208-221.

    doi: 10.1007/s00134-020-06331-9

  • Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States.

    Flythe JE, Assimon MM, Tugman MJ, Chang EH, Gupta S, Shah J, Sosa MA, Renaghan AD, Melamed ML, Wilson FP, Neyra JA, Rashidi A, Boyle SM, Anand S, Christov M, Thomas LF, Edmonston D, Leaf DE; STOP-COVID Investigators.

    Am J Kidney Dis. 2021 Feb;77(2):190-203.e1.

    doi: 10.1053/j.ajkd.2020.09.003

  • AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19.

    Gupta S, Coca SG, Chan L, Melamed ML, Brenner SK, Hayek SS, Sutherland A, Puri S, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Schenck EJ, Goyal N, Hedayati SS, Dy R, Bansal A, Athavale A, Nguyen HB, Vijayan A, Charytan DM, Schulze CE, Joo MJ, Friedman AN, Zhang J, Sosa MA, Judd E, Velez JCQ, Mallappallil M, Redfern RE, Bansal AD, Neyra JA, Liu KD, Renaghan AD, Christov M, Molnar MZ, Sharma S, Kamal O, Boateng JO, Short SAP, Admon AJ, Sise ME, Wang W, Parikh CR, Leaf DE; STOP-COVID Investigators.

    J Am Soc Nephrol. 2021 Jan;32(1):161-176.

    doi: 10.1681/ASN.2020060897

  • Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19.

    Gupta S, Wang W, Hayek SS, Chan L, Mathews KS, Melamed ML, Brenner SK, Leonberg-Yoo A, Schenck EJ, Radbel J, Reiser J, Bansal A, Srivastava A, Zhou Y, Finkel D, Green A, Mallappallil M, Faugno AJ, Zhang J, Velez JCQ, Shaefi S, Parikh CR, Charytan DM, Athavale AM, Friedman AN, Redfern RE, Short SAP, Correa S, Pokharel KK, Admon AJ, Donnelly JP, Gershengorn HB, Douin DJ, Semler MW, Hernán MA, Leaf DE; STOP-COVID Investigators.

    JAMA Intern Med. 2021 Jan 1;181(1):41-51.

    doi: 10.1001/jamainternmed.2020.6252

  • Outcomes of critically ill solid organ transplant patients with COVID-19 in the United States.

    Molnar MZ, Bhalla A, Azhar A, Tsujita M, Talwar M, Balaraman V, Sodhi A, Kadaria D, Eason JD, Hayek SS, Coca SG, Shaefi S, Neyra JA, Gupta S, Leaf DE, Kovesdy CP; STOP-COVID Investigators.

    Am J Transplant. 2020 Nov;20(11):3061-3071.

    doi: 10.1111/ajt.16280

  • Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study.

    Biran N, Ip A, Ahn J, Go RC, Wang S, Mathura S, Sinclaire BA, Bednarz U, Marafelias M, Hansen E, Siegel DS, Goy AH, Pecora AL, Sawczuk IS, Koniaris LS, Simwenyi M, Varga DW, Tank LK, Stein AA, Allusson V, Lin GS, Oser WF, Tuma RA, Reichman J, Brusco L Jr, Carpenter KL, Costanzo EJ, Vivona V, Goldberg SL.

    Lancet Rheumatol. 2020 Oct;2(10):e603-e612.

    doi: 10.1016/S2665-9913(20)30277-0

  • In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study.

    Hayek SS, Brenner SK, Azam TU, Shadid HR, Anderson E, Berlin H, Pan M, Meloche C, Feroz R, O'Hayer P, Kaakati R, Bitar A, Padalia K, Perry D, Blakely P, Gupta S, Shaefi S, Srivastava A, Charytan DM, Bansal A, Mallappallil M, Melamed ML, Shehata AM, Sunderram J, Mathews KS, Sutherland AK, Nallamothu BK, Leaf DE; STOP-COVID Investigators.

    BMJ. 2020 Sep 30;371:m3513.

    doi: 10.1136/bmj.m3513

  • Hydroxychloroquine and tocilizumab therapy in COVID-19 patients-An observational study.

    Ip A, Berry DA, Hansen E, Goy AH, Pecora AL, Sinclaire BA, Bednarz U, Marafelias M, Berry SM, Berry NS, Mathura S, Sawczuk IS, Biran N, Go RC, Sperber S, Piwoz JA, Balani B, Cicogna C, Sebti R, Zuckerman J, Rose KM, Tank L, Jacobs LG, Korcak J, Timmapuri SL, Underwood JP, Sugalski G, Barsky C, Varga DW, Asif A, Landolfi JC, Goldberg SL.

    PLoS One. 2020 Aug 13;15(8):e0237693.

    doi: 10.1371/journal.pone.0237693

  • Clinical Response-Guided tPA and DNAse Administration as Rescue Treatment for Postoperative Empyema.

    Knauer, A, Stewart G, Go R.

    Pleura. 2019;6:4-9.

    doi: 10.33973/Pleura36311

  • Pulmonary Kaposi's Sarcoma and Its Complications in the HAART Era: A Contemporary Case-Based Review.

    Epelbaum O, Go R, Patel G, Braman S.

    Lung. 2016 Feb;194(1):163-9.

    doi: 10.1007/s00408-015-9830-7

  • Pulmonary Kaposi's Sarcoma and Its Complications in the HAART Era: A Contemporary Case-Based Review.

    Epelbaum O, Go R, Patel G, Braman S.

    Lung. 2016 Feb;194(1):163-9.

    doi: 10.1007/s00408-015-9830-7

  • Prinicipal Investigator

    (2021) Antithrombotic Therapy to Ameliorate Complications of COVID-19 (ATTACC) in Collaboration with Accelerating COVID-19 therapeutic interventions and vaccines (ACTIV-4).

    PRO2020-1340.

  • Prinicipal Investigator

    (2021) Long Term Follow-up Study of Patients with COVID-19 Associated Pneumonia Who Participated in Designated Genentech/Roche Sponsored Study or Genentech/Roche Supported Investigator Initiated Placebo Controlled or Active Controlled Study.

  • Sub-Investigator

    (2021) Phase I/Phase II Trial of Allogeneic Hybrid TREG/Th2 Cell (RAPA- 501-ALLO) Therapy for Severe, Post-Intubation Stage 3 COVID-19 Disease.

    PI: Michele Donato.

  • Principal Investigator

    (2020) ROCHE WA42380-COVACTA.

    PRO2020-0341.

    This is a multicenter double blinded randomized control trial of tocilizumab 8 mg/kg versus placebo in COVID-19. Primary Outcome is 28 day mortality on 7 category ordinal scale. Funding: Hoffman-LaRoche.

  • Sub-Investigator

    (2020) Expanded Access Protocol-HMH Convalescent Plasma.

    PRO2020-0663.

    PI: Michele Donato.

    This is a multicenter prospective study on the use of convalescent plasma in COVID-19.

  • Sub-Investigator

    (2020) Phase II Randomized Study of Convalescent Plasma – COVID-19.

    PRO2020-0542.

    PI: Michele Donato.

    This is a multicenter prospective study on the use of convalescent plasma in COVID-19.

  • Sub-Investigator

    (2020) COVID-19 Neurologic Manifestations via University of Pittsburgh.

    PRO2020-1113.

    PI: Florian Thomas.

    This is an international multicenter study involving neurologic complications of COVID-19 in critically ill patients.

  • Principal Investigator

    (2019) Vitamin C in Patients after Cardiac Arrest With or Without Targeted Temperature Management.

    Site: Orange Regional Medical Center.

    IRB: HH1846.

  • Principal Investigator

    (2019) Randomized Control Trial on Complicated Parapneumonic Effusion and Empyema to once a day intrapleural TPA and DNAse versus twice a day dose of Concurrent Intrapleural TPA and DNase.

    Site: Orange Regional Medical Center.

    IRB: HH1845.

  • Principal Investigator

    (2021) Methylprednisolone and 60 Day Mortality in Hospitalized COVID-19.

    PRO2020-0485.

  • Sub-Investigator

    (2020) Epidemiology of COVID-19 Positive Patients in the ICU. PRO2020- 0335.

    PI: Samantha Brenner.

    This is a multi-center retrospective cohort on the risk factors of hospitalized covid-19 patients, AKI in COVID-19 patients, and treatment in COVID-19.

  • Sub-Investigator

    (2020) COVID Neurological Manifestations.

    PRO2020-0474.

    PI: Florian Thomas.

    This is a retrospective cohort on neurologic manifestations in outpatient and inpatient COVID-19 patients.

  • Sub-Investigator

    (2020) Cardiovascular Data for COVID-19 Patients.

    PRO2020-0544.

    PI: Joseph Parrillo.

    This is a retrospective cohort on shock in hospitalized COVID-19 patients, arrthymias in hospitalized COVID-19 patients, and thromboembolic events in hospitalized COVID-19 patients at HUMC.

  • Sub-Investigator

    (2020) Post Tachycardia Syndrome.

    PRO2020-0938

    PI: Sameer Jamal.

    This is prospective study on post COVID-19 and residual tachycardia upon discharge.

  • Sub-Investigator

    (2020) Vaping and COVID-19 Critical Illness.

    PRO2020-0695

    PI: Karan Omidvari.

    This is a case series on vaping and covid-19.